Experimental verification of therapeutic doses for the superficially-placed tumor radiotherapy with heavy ions at HIRFL

LIU Xin-Guo; LI Qiang; WU Qing-Feng; TAO Jia-Jun; JIN Xiao-Dong

doi:10.1088/1674-1137/33/2/014

Chinese Physics C> 2009, Vol. 33> Issue(2) : 151-155 DOI: 10.1088/1674-1137/33/2/014

Experimental verification of therapeutic doses for the superficially-placed tumor radiotherapy with heavy ions at HIRFL

Abstract
HTML
Reference
Related

PDF

Abstract：
Up to now, clinical trials of heavy-ion radiotherapy for superficially placed tumors have been carried out for six times and over 60 selected patients have been treated with 80—100 MeV/u carbon ions supplied by the Heavy Ion Research Facility in Lanzhou (HIRFL) at the Institute of Modern Physics, Chinese Academy of Sciences since November, 2006. A passive irradiation system and a dose optimization method for radiotherapy with carbon-ion beams have been developed. Experimental verification of longitudinally therapeutic dose distributions was conducted under the condition of simulating patient treatment in the therapy terminal at HIRFL. The measured depth-dose distributions basically coincide with the expected ones. These results indicate that the irradiation system and the dose optimization method are effective in the ongoing carbon-ion radiotherapy for shallow-seated tumors at HIRFL.

References

[1]

. Kraft G. Prog. Part. Nucl. Phys., 2000, 45: S4732. LI Q. Adv. Space Res., 2007, 40: 4553. ZHANG H, LI S, LI Q et al. First Clinical Trial of Cancer Therapy with Heavy Ions at IMP. IMP HIRFL Annual Report, Beijing: Atomic Energy Press, 2006. 834. DAI Z Y, LI Q, YAN Z et al. HEP NP, 2006, 30(9): 920(in Chinese)5. DAI Z Y, LI Q, XIAO G Q et al. HEP NP, 2007, 31(7):655. (in Chinese)6. LI Q, DAI Z Y, YAN Z et al. Med. Bio. Eng. Comput.,2007, 45(11): 10377. TANG B et al. Nuclear Electronics Detection Technol-ogy, 2008,28(4): 699 (in Chinese)8. MAO R S et al. High Power Laser and Particle Beams,2008, 20(9): 1537 (in Chinese)9. Weber U, Kraft G. Phys. Med. Biol., 1999, 44: 276510. Futami Y, Kanai T, Fujita M. Nucl. Instrum. MethodsPhys. Res. A, 1999, 430: 14311. Scha ner B, Kanai T, Futami Y. Med. Phys., 2000, 27(4):71612. Kanematsu N, Endo M, Futami Y. Med. Phys., 2002,29(12): 282313. Kanai T, Furusawa Y, Fukutsu K. et al. Radiat. Res., 1997,147: 7814. Furusawa Y, Fukutsu K, Aoki M. et al. Radiat. Res., 2000,154: 48515. Sihver L, Schardt D, Kanai T. Jpn. J. Med. Phys., 1998,18(1): 116. Mitaro A, Kraft-Weyrather W, GeiB O. et al. Radiat. En-viron. Biophys., 1998, 37: 4717. Kramer M, WANG J F, Weyrather W. Phys. Med. Biol.,2003, 48: 206318. Kanai T, Endo M, Minohara S et al. Int. J. Radiat. Oncol.Biol. Phys., 1999, 44(1): 201

[1]	Wen-Jian Lin , Jian-Wei Zhao , Bao-Hua Sun , Liu-Chun He , Wei-Ping Lin , Chuan-Ye Liu , Isao Tanihata , Satoru Terashima , Yi Tian , Feng Wang , Meng Wang , Guang-Xin Zhang , Xue-Heng Zhang , Li-Hua Zhu , Li-Min Duan , Rong-Jiang Hu , Zhong Liu , Chen-Gui Lu , Pei-Pei Ren , Li-Na Sheng , Zhi-Yu Sun , Shi-Tao Wang , Tao-Feng Wang , Zhi-Guo Xu , Yong Zheng . Plastic scintillation detectors for precision Time-of-Flight measurements of relativistic heavy ions. Chinese Physics C, 2017, 41(6): 066001. doi: 10.1088/1674-1137/41/6/066001
[2]	Yuan-Lin Yan , Xin-Guo Liu , Zhong-Ying Dai , Yuan-Yuan Ma , Peng-Bo He , Guo-Sheng Shen , Teng-Fei Ji , Hui Zhang , Qiang Li . Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy. Chinese Physics C, 2017, 41(9): 098201. doi: 10.1088/1674-1137/41/9/098201
[3]	Jun-Kui Xu , You-Wu Su , Wu-Yuan Li , Wei-Wei Yan , Zong-Qiang Li , Wang Mao , Cheng-Guo Pang , Chong Xu . Study of neutron dose equivalent at the HIRFL deep tumor therapy terminal. Chinese Physics C, 2017, 41(6): 068201. doi: 10.1088/1674-1137/41/6/068201
[4]	Cao-Jie Shao , De-Yang Yu , Rong-Chun Lu , Tie-Cheng Zhao , Rui-Shi Mao , Jie Li , Ying-Li Xue , Wei Wang , Bian Yang , Ming-Wu Zhang , Jun-Liang Liu , Zhang-Yong Song , Xiao-Hong Cai , Xi-Meng Chen , Da-Yu Yin , Li-Jun Mao , Xiao-Dong Yang , Jian-Cheng Yang , You-Jin Yuan . Determination of internal-target thickness and experimental luminosity from beam energy loss at HIRFL-CSRe. Chinese Physics C, 2016, 40(11): 117002. doi: 10.1088/1674-1137/40/11/117002
[5]	LIU Xing-Xing , ZHANG Gao-Long , ZHANG Huan-Qiao . Study of fusion Q-value rule in sub-barrier fusion of heavy ions. Chinese Physics C, 2015, 39(7): 074101. doi: 10.1088/1674-1137/39/7/074101
[6]	ZHANG Xiao-Hu , YUAN You-Jin , XIA Jia-Wen , YIN Xue-Jun , DU Heng , LI Zhong-Shan . Conceptional design of a heavy ion linac injector for HIRFL-CSRm. Chinese Physics C, 2014, 38(10): 107002. doi: 10.1088/1674-1137/38/10/107002
[7]	HAN Jian-Long , MA Jun-Bing , CAO Xi-Guang , WANG Qi , WANG Jian-Song , YANG Yan-Yun , MA Peng , HUANG Mei-Rong , JIN Shi-Lun , RONG Xin-Juan , BAI Zhen , FU Fen , HU Qiang , CHEN Ruo-Fu , XU Shi-Wei , CHEN Jiang-Bo , JIN Lei , LI Yong , ZHAO Ming-Hui , XU Hu-Shan . Performance of a double sided silicon strip detector as a transmission detector for heavy ions. Chinese Physics C, 2014, 38(5): 056202. doi: 10.1088/1674-1137/38/5/056202
[8]	HE Peng-Bo , LI Qiang , LIU Xin-Guo . Experimental measurement of the correlation between CT number and heavy ion range. Chinese Physics C, 2012, 36(10): 954-957. doi: 10.1088/1674-1137/36/10/006
[9]	YIN Hong-Jie , ZHANG Wei-Ning . Interferometry imaging for the evolving source in heavy ion collisions at HIRFL-CSR energy. Chinese Physics C, 2012, 36(3): 216-221. doi: 10.1088/1674-1137/36/3/005
[10]	DAI Zhong-Ying , LI Qiang , LIU Xin-Guo , JIN Xiao-Dong , HUANG Qi-Yan , XIAO Guo-Qing . Active spot-scanning test with heavy ions at HIRFL-CSR. Chinese Physics C, 2012, 36(8): 784-791. doi: 10.1088/1674-1137/36/8/018
[11]	TIAN Kai , CAO Zhou , XUE Yu-Xiong , YANG Shi-Yu . Comparison study of the charge density distribution induced by heavy ions and pulsed lasers in silicon. Chinese Physics C, 2010, 34(1): 148-151. doi: 10.1088/1674-1137/34/1/028
[12]	SHENG Li-Na , SONG Ming-Tao , ZHANG Xiao-Qi , YANG Xiao-Tian , GAO Da-Qing , HE Yuan , ZHANG Bin , LIU Jie , SUN You-Mei , DANG Bing-Rong , LI Wen-Jian , SU Hong , MAN Kai-Di , GUO Yi-Zhen , WANG Zhi-Guang , ZHAN Wen-Long . Design of the IMP microbeam irradiation system for 100 MeV/u heavy ions. Chinese Physics C, 2009, 33(4): 315-320. doi: 10.1088/1674-1137/33/4/016
[13]	YU Li-Li , ZHANG Wei-Ning , HUO Lei , ZHANG Jing-Bo , . Two-pion interferometry in heavy ion collisions at HIRFL-CSR energy. Chinese Physics C, 2008, 32(11): 897-902. doi: 10.1088/1674-1137/32/11/010
[14]	YUAN You-Jin , XIA Jia-Wen , LI Peng , YANG Xiao-Dong . Charge stripping accumulation of light heavy ions in HIRFL-CSR main ring. Chinese Physics C, 2008, 32(9): 754-757. doi: 10.1088/1674-1137/32/9/014
[15]	MAO Li-Jun , YANG Xiao-Dong , XIA Jia-Wen , WEI Bao-Wen . Intrabeam Scattering of Heavy Ions at HIRFL-CSR. Chinese Physics C, 2007, 31(10): 947-951.
[16]	DAI Zhong-Ying , LI Qiang , XIAO Guo-Qing , JIN Xiao-Dong , YAN Zheng . Capability Verification of the Beam Delivery System in the Superficially-Placed Tumor Therapy Terminal at HIRFL. Chinese Physics C, 2007, 31(7): 655-659.
[17]	DAI Zhong-Ying , LI Qiang , YAN Zheng , JIN Xiao-Dong , HU Zheng-Guo , XIAO Guo-Qing . Physical Property Measurement of Therapeutic Carbon Ion Beam in the Shallow-Seated Tumor Therapy Terminal at HIRFL. Chinese Physics C, 2006, 30(9): 920-924.
[18]	Tan Jilian , Zhang Jinxia , Jin Genming , Zhang Huanqiao , Qian Xing , Liu Zuhua , Xu Jincheng . Bi-dimension Position Sensitive Detector Used in the Study of Fusion Fission of Heavy Ions at the Sub-Coulomb Barrier Energy Region. Chinese Physics C, 1997, 21(S2): 1-8.
[19]	Hu Jimin , Zhong Yunxiao . Interaction Potential Between Heavy Ions in Fusion Reactions. Chinese Physics C, 1996, 20(S4): 373-378.
[20]	Feng Enpu , Zhu Yongtai , Guo Zhongyan , Qiao Weimin , Zhan Wenlong , Shen Wenqing , Wang Xiaoqiu , Wang Bing , Yin Shuzhi , Feng Jun , Liu Guanhua , Xi Hongfei , Fan Enjie , Zhu Xiang , Zhou Jianqun , Zeng Yaowu . The Experimental Terminal with Large-Area Ionization Chambers at Lanzhou Heavy-Ion Accelerator. Chinese Physics C, 1991, 15(S2): 133-140.

Access

Get Citation

LIU Xin-Guo, LI Qiang, WU Qing-Feng, TAO Jia-Jun and JIN Xiao-Dong. Experimental verification of therapeutic doses for the superficially-placed tumor radiotherapy with heavy ions at HIRFL[J]. Chinese Physics C, 2009, 33(2): 151-155. doi: 10.1088/1674-1137/33/2/014

RIS(for EndNote,Reference Manager,ProCite)

BibTex

Txt

Milestone

Received: 2008-05-04
Revised: 2008-07-09

Article Metric

Article Views(4125)
PDF Downloads(698)
Cited by(0)

Policy on re-use

To reuse of subscription content published by CPC, the users need to request permission from CPC, unless the content was published under an Open Access license which automatically permits that type of reuse.

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Experimental verification of therapeutic doses for the superficially-placed tumor radiotherapy with heavy ions at HIRFL

Corresponding author: LI Qiang,

Received Date: 2008-05-04

Accepted Date: 2008-07-09

Available Online: 2009-02-05

Abstract:

Up to now, clinical trials of heavy-ion radiotherapy for superficially placed tumors have been carried out for six times and over 60 selected patients have been treated with 80—100 MeV/u carbon ions supplied by the Heavy Ion Research Facility in Lanzhou (HIRFL) at the Institute of Modern Physics, Chinese Academy of Sciences since November, 2006. A passive irradiation system and a dose optimization method for radiotherapy with carbon-ion beams have been developed. Experimental verification of longitudinally therapeutic dose distributions was conducted under the condition of simulating patient treatment in the therapy terminal at HIRFL. The measured depth-dose distributions basically coincide with the expected ones. These results indicate that the irradiation system and the dose optimization method are effective in the ongoing carbon-ion radiotherapy for shallow-seated tumors at HIRFL.

HTML

Reference (1)

Experimental verification of therapeutic doses for the superficially-placed tumor radiotherapy with heavy ions at HIRFL

Abstract：

References

Access

Article Metrics

Metrics

通讯作者: 陈斌, bchen63@163.com

Email This Article