A simulation study of a dual-plate in-room PET system for dose verification in carbon ion therapy

CHEN Ze; HU Zheng-Guo; CHEN Jin-Da; ZHANG Xiu-Ling; GUO Zhong-Yan; XIAO Guo-Qing; SUN Zhi-Yu; HUANG Wen-Xue; WANG Jian-Song

doi:10.1088/1674-1137/38/8/088202

Chinese Physics C> 2014, Vol. 38> Issue(8) : 088202 DOI: 10.1088/1674-1137/38/8/088202

A simulation study of a dual-plate in-room PET system for dose verification in carbon ion therapy

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During carbon ion therapy, lots of positron emitters such as ¹¹C, ¹⁵O, ¹⁰C are generated in irradiated tissues by nuclear reactions, and can be used to track the carbon beam in the tissue by a positron emission tomography (PET) scanner. In this study, an dual-plate in-room PET scanner has been designed and evaluated based on the GATE simulation platform to monitor patient dose in carbon ion therapy. The dual-plate PET is designed to avoid interference with the carbon beamline and with patient positioning. Its performance was compared with that of four-head and full-ring PET scanners. The dual-plate, four-head and full-ring PET scanners consisted of 30, 60, 60 detector modules, respectively, with a 36 cm distance between directly opposite detector modules for dose deposition measurements. Each detector module consisted of a 24×24 array of 2 mm×2 mm×18 mm LYSO pixels coupled to a Hamamatsu H8500 PMT. To estimate the production yield of positron emitters, a 10 cm×15 cm×15 cm cuboid PMMA phantom was irradiated with 172, 200, 250 MeV/u ¹²C beams. 3D images of the activity distribution measured by the three types of scanner are produced by an iterative reconstruction algorithm. By comparing the longitudinal profile of positron emitters along the carbon beam path, it is indicated that use of the dual-plate PET scanner is feasible for monitoring the dose distribution in carbon ion therapy.

References

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CHEN Ze, HU Zheng-Guo, CHEN Jin-Da, ZHANG Xiu-Ling, GUO Zhong-Yan, XIAO Guo-Qing, SUN Zhi-Yu, HUANG Wen-Xue and WANG Jian-Song. A simulation study of a dual-plate in-room PET system for dose verification in carbon ion therapy[J]. Chinese Physics C, 2014, 38(8): 088202. doi: 10.1088/1674-1137/38/8/088202

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Received: 2013-10-09
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

A simulation study of a dual-plate in-room PET system for dose verification in carbon ion therapy

Corresponding author: HU Zheng-Guo,

Received Date: 2013-10-09

Accepted Date: 1900-01-01

Available Online: 2014-08-05

Abstract: During carbon ion therapy, lots of positron emitters such as ¹¹C, ¹⁵O, ¹⁰C are generated in irradiated tissues by nuclear reactions, and can be used to track the carbon beam in the tissue by a positron emission tomography (PET) scanner. In this study, an dual-plate in-room PET scanner has been designed and evaluated based on the GATE simulation platform to monitor patient dose in carbon ion therapy. The dual-plate PET is designed to avoid interference with the carbon beamline and with patient positioning. Its performance was compared with that of four-head and full-ring PET scanners. The dual-plate, four-head and full-ring PET scanners consisted of 30, 60, 60 detector modules, respectively, with a 36 cm distance between directly opposite detector modules for dose deposition measurements. Each detector module consisted of a 24×24 array of 2 mm×2 mm×18 mm LYSO pixels coupled to a Hamamatsu H8500 PMT. To estimate the production yield of positron emitters, a 10 cm×15 cm×15 cm cuboid PMMA phantom was irradiated with 172, 200, 250 MeV/u ¹²C beams. 3D images of the activity distribution measured by the three types of scanner are produced by an iterative reconstruction algorithm. By comparing the longitudinal profile of positron emitters along the carbon beam path, it is indicated that use of the dual-plate PET scanner is feasible for monitoring the dose distribution in carbon ion therapy.

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